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dc.contributor.authorGungorduk, Kemal
dc.contributor.authorPlett, Helmut
dc.contributor.authorGulseren, Varol
dc.contributor.authorMeydanli, Mutlu
dc.contributor.authorBoyraz, Gokhan
dc.contributor.authorOzdemir, IsaAykut
dc.contributor.authorSahin, Hanifi
dc.contributor.authorSenol, Taylan
dc.contributor.authorYildirim, Nuri
dc.contributor.authorTuran, Taner
dc.contributor.authorOge, Tayfun
dc.contributor.authorGokcu, Mehmet
dc.contributor.authorTaskin, Salih
dc.contributor.authorAyhan, Ali
dc.contributor.authorAtaseven, Beyhan
dc.description.abstractAim: The clinicopathologic characteristics, recurrence patterns, and survival of patients with grade 3 endometrial cancer (G3-EAC) and uterine carcinosarcoma (UCS) were compared. Materials and Methods: The medical records of patients treated for G3-EAC and UCS between January 1996 and December 2016 at 11 gynecologic oncology centers in Turkey and Germany were analyzed. Results: Of all patients included in the study, 161 (45.1%) were diagnosed with UCS and 196 (54.9%) with G3-EAC at FIGO stage I-II (early stage) disease. The recurrence rate was higher in patients with UCS than in those with G3-EAC (17.4 vs. 9.2%, p = 0.02). The 5-year disease-free survival (DFS; 75.2 and 80.8%, respectively; p = 0.03) and overall survival (OS; 79.4 and 83.4%, respectively; p = 0.04) rates were significantly lower in the UCS group compared to the G3-EAC group. UCS histology was an independent prognostic factor for decreased 5-year DFS (HR 1.8, 95% CI 1.2-3.2; p = 0.034) and OS (HR 2.7, 95% CI 1.3-6.9; p = 0.041) rates. Conclusions: The recurrence rate was higher in UCS patients than in G3-EAC patients, regardless of disease stage. DFS and OS were of shorter duration in UCS than in G3-EAC patients. Adequate systematic lymphadenectomy and omentectomy were an independent prognostic factor for increased 5-year DFS and OS rates.en_US
dc.subjectEndometrial canceren_US
dc.subjectGrade 3 endometrial canceren_US
dc.subjectUterine carcinosarcomaen_US
dc.titleIs the Oncological Outcome of Early Stage Uterine Carcinosarcoma Different from That of Grade 3 Endometrioid Adenocarcinoma?en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US

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