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dc.contributor.authorCeran, Mehmet Ufuk
dc.contributor.authorTasdemir, Umit
dc.contributor.authorColak, Eser
dc.contributor.authorGungor, Tayfun
dc.date.accessioned2021-02-28T13:27:02Z
dc.date.available2021-02-28T13:27:02Z
dc.date.issued2019
dc.identifier.issn1757-2215en_US
dc.identifier.urihttps://ovarianresearch.biomedcentral.com/track/pdf/10.1186/s13048-019-0491-7.pdf
dc.identifier.urihttp://hdl.handle.net/11727/5436
dc.description.abstractSubjectiveThe aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).MethodTwo hundred forty four patients that underwent operation with the diagnosis of invasive EOC between 2006 and 2014 were included in the study. The date of operation, date of recurrence and final mortality evaluations were performed for survival analysis. The sensitivity, specificity, PPV and NPV were separately calculated with ROC analysis. Survival analysis was carried out with Kaplan Meier-Log Rank Method.ResultsFive-years overall survival rate was 56, 9% and 5-year disease-free survival (DFS) rate was 45,5%. Advanced disease stage, moderate-poor tumor differentiation, and the presence of recurrence were determined to have significant inverse relation at mean survival and 5-year survival rates. Neutrophil/lymphocyte ratio (NLR) and Platelet lymphocyte ratio (PLR) had prognostic effect on both DFS and overall survival based upon the cut-off values determined in the study (PLR=231, s36, NLR=3,83). Histopathological subtypes were not found to have any prognostic value. In correlation analysis, PLR and NLR had positive correlation with each other and negative correlation with overall survival.ConclusionsInflammatory markers such as NLR and PLR have independent prognostic value for women who undergo surgery for invasive EOC.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1186/s13048-019-0491-7en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpithelial ovarian canceren_US
dc.subjectSurvivalen_US
dc.subjectPLRen_US
dc.subjectNLRen_US
dc.titleCan complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysisen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF OVARIAN RESEARCHen_US
dc.identifier.volume12en_US
dc.identifier.wos000458451500001en_US
dc.identifier.scopus2-s2.0-85061355197en_US
dc.contributor.pubmedID30744662en_US
dc.contributor.orcID0000-0003-1923-2373en_US
dc.contributor.orcID0000-0002-8184-7531en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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