dc.contributor.author | Sahin, Hanifi | |
dc.contributor.author | Meydanli, Mehmet Mutlu | |
dc.contributor.author | Sari, Mustafa Erkan | |
dc.contributor.author | Kocaman, Eda | |
dc.contributor.author | Cuylan, Zeliha Fırat | |
dc.contributor.author | Yalcin, Ibrahim | |
dc.contributor.author | Coban, Gonca | |
dc.contributor.author | Ozen, Ozlem | |
dc.contributor.author | Sirvan, Levent | |
dc.contributor.author | Gungor, Tayfun | |
dc.contributor.author | Ayhan, Ali | |
dc.date.accessioned | 2021-03-03T07:11:29Z | |
dc.date.available | 2021-03-03T07:11:29Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1028-4559 | en_US |
dc.identifier.uri | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1028455918302900?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1028455918302900%3Fshowall%3Dtrue&referrer=http:%2F%2Fapps.webofknowledge.com%2F | |
dc.identifier.uri | http://hdl.handle.net/11727/5471 | |
dc.description.abstract | Objective: The purpose of this study was to determine the patterns of failure and prognostic factors for lymphovascular space invasion (LVSI)-positive endometrioid endometrial cancer (EC) patients in the setting of negative lymph nodes (LNs).
Materials and methods: A multicenter, retrospective department database review was performed to identify LVSI-positive patients with disease surgically confined to the uterus at two gynecologic oncology centers in Turkey. Demographic, clinicopathological and survival data were collected.
Results: We identified 185 LVSI-positive women with negative LNs during the study period. Fifty-five (29.7%) were classified as Stage IA, 94 (50.8%) as Stage IB, and 36 (19.5%) as Stage II. The median age at diagnosis was 59 years and the median duration of follow-up was 44 months. The total number of the recurrences was 12 (6.5%). We observed 5 (2.9%) loco-regional recurrences, 3 (1.5%) retroperitoneal failures, and 4 (2.0%) distant relapses. The 5-year progression-free survival (PFS) was 86.1% while the 5-year overall survival (OS) rate was 87.7%. Grade 3 histology (Hazard Ratio [HR] 2.9, 95% Confidence Interval [CI] 1.02-8.50; p = 0.04), cervical stromal invasion (HR 4.5, 95% CI 1.61-12.79; p = 0.004) and age > 60 years (HR 5.8, 95% CI 1.62-21.32; p = 0.007) were found to be independent prognostic factors for decreased OS. Adjuvant treatment did not appear as a prognostic factor for OS even in univariate analysis.
Conclusion: The recurrence rate among LVSI-positive endometrioid EC patients is low in the setting of negative LNs. However, one out of three patients with a recurrence experiences distant relapses which usually portend worse outcomes. (C) 2018 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1016/j.tjog.2018.11.016 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Endometrioid adenocarcinoma | en_US |
dc.subject | Endometrial cancer | en_US |
dc.subject | Recurrence | en_US |
dc.subject | Lymphovascular space invasion | en_US |
dc.subject | Negative lymph nodes | en_US |
dc.title | Recurrence patterns and prognostic factors in lymphovascular space invasion-positive endometrioid endometrial cancer surgically confined to the uterus | en_US |
dc.type | article | en_US |
dc.relation.journal | TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 82 | en_US |
dc.identifier.endpage | 89 | en_US |
dc.identifier.wos | 000455435800016 | en_US |
dc.identifier.scopus | 2-s2.0-85057715606 | en_US |
dc.contributor.pubmedID | 30638487 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |