Browsing Eczacılık Fakültesi / Faculty of Pharmacy by Title
Now showing items 8-27 of 35
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Detection of COVID-19 by Machine Learning Using Routine Laboratory Tests
(2021)Objectives The present study aimed to develop a clinical decision support tool to assist coronavirus disease 2019 (COVID-19) diagnoses with machine learning (ML) models using routine laboratory test results. Methods We ... -
Development of Cyclosporine A Nanosuspension: Cytotoxicity and Permeability on Caco-2 Cell Lines
(2021)Cyclosporine A is a calcineurin inhibitor and is usually used as an immunosuppressant medication. The main purpose of this study is to develop nanosuspension of polypeptide cyclosporine A by using the wet milling method ... -
Drug-related problems and health-related quality of life among chronic disease patients in a rural region of North Cyprus
(2022)Purpose: To evaluate the various types of drug-related problems (DRPs) and health-related quality of life (HRQoL) among chronic disease patients in a rural region of North Cyprus.Methods: A cross-sectional study of patients ... -
Editorial, Special Issue BBBB
(2021) -
Electrochemical Detection of Antioxidant Activities of 4-Indolyl-5-Oxo-6,6 (Or 7,7)-Dimethyl-1,4,5,6,7,8-Hexahydroquinoline Derivatives
(2021)Antioxidants used in different medical and industrial fields in order to prevent and delay oxidative stress. They play a crucial role in the protecting biological systems against many diseases. 1,4-dihydropyridines are ... -
Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
(2021)Purpose The objective of this study was to optimize the Flurbiprofen (FB) nanosuspension (NS) based gel and to investigate the in vitro release, ex vivo permeation, the plasma concentration-time profile and pharmacokinetic ... -
Estimation of Low-Density Lipoprotein Cholesterol Concentration Using Machine Learning
(2021)Objective Low-density lipoprotein cholesterol (LDL-C) can be estimated using the Friedewald and Martin-Hopkins formulas. We developed LDL-C prediction models using multiple machine learning methods and investigated the ... -
Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation
(2021)Aim The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD). Methods Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in ... -
Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats
(2021)The objective of this study is to develop a new self-nanoemulsifying system containing exendin-4 with or without enzyme inhibitor chymostatin and to evaluate the effects of oral administration of exendin-4 and exendin-4/ ... -
Exometabolomic analysis of susceptible and multi-drug resistant Pseudomonas aeruginosa
(2022)Multidrug resistant (MDR) Pseudomonas aeruginosa strains have recently become one of the major public health concerns worldwide leading to difficulties in selecting appropriate antibiotic treatment. Thus, it is important ... -
Food plant with antioxidant, tyrosinase inhibitory and antimelanoma activity: Prunus mahaleb L
(2022)Prunus mahaleb L. seeds are used as spice and folk remedies in many countries. The aim of this study was bioactivity guided isolation and characterization phytoconstituents of P. mahaleb which have been studied very limited ... -
In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals
(2021)Objectives: The current study focused on the evaluation of the cytotoxic effect and permeability of ziprasidone hydrochloride monohydrate (ZHM) nanocrystals on Caco-2 cells. Materials and Methods: ZHM nanocrystals were ... -
Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer
(2021)The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is commercially available only in subcutaneous form, several attempts have ... -
The Phytochemical Profile and Biological Activity of Malva neglecta Wallr. in Surgically Induced Endometriosis Model in Rats
(2022)Leaves and aerial parts of Malva neglecta Wallr. have been traditionally used in Anatolia for the treatment of pain, inflammation, hemorrhoids, renal stones, constipation, and infertility. This study investigated the effects ... -
Potential drug-drug interactions of immunosuppressants in kidney transplant recipients: comparison of drug interaction resources
(2022)Background Drug-drug interactions are frequently observed in kidney transplant recipients due to polypharmacy and use of immunosuppressants. However, there is only one study evaluating clinically relevant potential drug-drug ... -
Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application
(2020)Flurbiprofen (FB) is an analgesic and anti-inflammatory drug, but its low water solubility (BCS Class II) limits its dermal bioavailability. The aim of this study is to develop a FB nanosuspension (NS) based gel and to ...
