Yazar "Oktay, Ayse Nur" için Eczacılık Fakültesi / Faculty of Pharmacy listeleme
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Cyclodextrin-Based Nanogel Of Flurbiprofen For Dermal Application: In Vitro Studies And In Vivo Skin Irritation Evaluation
Oktay, Ayse Nur; Celebi, Nevin; Ilbasmis-Tamer, Sibel; Kaplanog, Guelnur Take (2022)The aim of this study was to develop and characterize flurbiprofen (FB)-loaded cyclodextrin (CD) based nanogel formulations for dermal application. Nanogels were produced via emulsification solvent evaporation and then ... -
Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
Oktay, Ayse Nur; Ilbasmis Tamer, Sibel; Uludag, Orhan; Celebi, Nevin (2021)Purpose The objective of this study was to optimize the Flurbiprofen (FB) nanosuspension (NS) based gel and to investigate the in vitro release, ex vivo permeation, the plasma concentration-time profile and pharmacokinetic ... -
Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application
Oktay, Ayse Nur; Ilbasmis-Tamer, Sibel; Han, Sevtap; Uludag, Orhan; Celebi, Nevin (2020)Flurbiprofen (FB) is an analgesic and anti-inflammatory drug, but its low water solubility (BCS Class II) limits its dermal bioavailability. The aim of this study is to develop a FB nanosuspension (NS) based gel and to ...