Browsing Eczacılık Fakültesi / Faculty of Pharmacy by Issue Date
Now showing items 1-20 of 33
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Preparation and in vitro/in vivo evaluation of flurbiprofen nanosuspension-based gel for dermal application
(2020)Flurbiprofen (FB) is an analgesic and anti-inflammatory drug, but its low water solubility (BCS Class II) limits its dermal bioavailability. The aim of this study is to develop a FB nanosuspension (NS) based gel and to ... -
Detection of COVID-19 by Machine Learning Using Routine Laboratory Tests
(2021)Objectives The present study aimed to develop a clinical decision support tool to assist coronavirus disease 2019 (COVID-19) diagnoses with machine learning (ML) models using routine laboratory test results. Methods We ... -
Estimation of Low-Density Lipoprotein Cholesterol Concentration Using Machine Learning
(2021)Objective Low-density lipoprotein cholesterol (LDL-C) can be estimated using the Friedewald and Martin-Hopkins formulas. We developed LDL-C prediction models using multiple machine learning methods and investigated the ... -
Unpredictable adverse effects of herbal products
(2021)Herbal products are being increasingly used all over the world for preventive and therapeutic purposes because of the belief of their safety. They have become an important part of health care system in many countries since ... -
In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals
(2021)Objectives: The current study focused on the evaluation of the cytotoxic effect and permeability of ziprasidone hydrochloride monohydrate (ZHM) nanocrystals on Caco-2 cells. Materials and Methods: ZHM nanocrystals were ... -
Editorial, Special Issue BBBB
(2021) -
Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer
(2021)The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is commercially available only in subcutaneous form, several attempts have ... -
Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats
(2021)The objective of this study is to develop a new self-nanoemulsifying system containing exendin-4 with or without enzyme inhibitor chymostatin and to evaluate the effects of oral administration of exendin-4 and exendin-4/ ... -
Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation
(2021)Aim The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD). Methods Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in ... -
Comparison of in vitro activities of plazomicin and other aminoglycosides against clinical isolates of Klebsiella pneumoniae and Escherichia coli
(2021)Objectives: To compare the in vitro activity of plazomicin and two older aminoglycosides (gentamicin and amikacin) against 180 isolates of Escherichia coli and Klebsiella pneumoniae, including subsets of 60 non-ESBL-producing, ... -
Development of Cyclosporine A Nanosuspension: Cytotoxicity and Permeability on Caco-2 Cell Lines
(2021)Cyclosporine A is a calcineurin inhibitor and is usually used as an immunosuppressant medication. The main purpose of this study is to develop nanosuspension of polypeptide cyclosporine A by using the wet milling method ... -
Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
(2021)Purpose The objective of this study was to optimize the Flurbiprofen (FB) nanosuspension (NS) based gel and to investigate the in vitro release, ex vivo permeation, the plasma concentration-time profile and pharmacokinetic ... -
Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients
(2021)There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the ... -
Electrochemical Detection of Antioxidant Activities of 4-Indolyl-5-Oxo-6,6 (Or 7,7)-Dimethyl-1,4,5,6,7,8-Hexahydroquinoline Derivatives
(2021)Antioxidants used in different medical and industrial fields in order to prevent and delay oxidative stress. They play a crucial role in the protecting biological systems against many diseases. 1,4-dihydropyridines are ... -
QbD based formulation optimization of semi-solid lipid nanoparticles as nano-cosmeceuticals
(2021)Nano-cosmeceuticals are cosmetic formulations containing nano-drug delivery systems to carry cosmetic active molecules to the relevant skin tissues. The purpose of this research is to develop and optimize the semi-solid ... -
Community pharmacists preparedness and barriers for cancer health promotion in North Cyprus
(2022)Introduction The role of a community pharmacist is well recognized in the literature as the most accessible health care provider that promotes health wellness and disease prevention. Evidence supports their role in cancer ...
