Ara
Toplam kayıt 14, listelenen: 1-10
Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer
(2021)
The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is commercially available only in subcutaneous form, several attempts have ...
Estimation of Low-Density Lipoprotein Cholesterol Concentration Using Machine Learning
(2021)
Objective Low-density lipoprotein cholesterol (LDL-C) can be estimated using the Friedewald and Martin-Hopkins formulas. We developed LDL-C prediction models using multiple machine learning methods and investigated the ...
Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats
(2021)
The objective of this study is to develop a new self-nanoemulsifying system containing exendin-4 with or without enzyme inhibitor chymostatin and to evaluate the effects of oral administration of exendin-4 and exendin-4/ ...
Enhanced Dermal Delivery of Flurbiprofen Nanosuspension Based Gel: Development and Ex Vivo Permeation, Pharmacokinetic Evaluations
(2021)
Purpose The objective of this study was to optimize the Flurbiprofen (FB) nanosuspension (NS) based gel and to investigate the in vitro release, ex vivo permeation, the plasma concentration-time profile and pharmacokinetic ...
Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation
(2021)
Aim
The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD).
Methods
Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in ...