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dc.contributor.authorArslan, Hande
dc.contributor.authorMusabak, Ugur
dc.contributor.authorSoy, Ebru H. Ayvazoglu
dc.contributor.authorAzap, Ozlem Kurt
dc.contributor.authorSayin, Burak
dc.contributor.authorAkcay, Sule
dc.contributor.authorHaberal, K. Murat
dc.contributor.authorAkdur, Aydincan
dc.contributor.authorYildirim, Sedat
dc.contributor.authorHaberal, Mehmet
dc.date.accessioned2021-06-15T09:00:45Z
dc.date.available2021-06-15T09:00:45Z
dc.date.issued2020
dc.identifier.issn1304-0855en_US
dc.identifier.urihttp://hdl.handle.net/11727/6017
dc.description.abstractObjectives: COVID-19 is a great threat to the modern world and significant threat to immunocompromised patients, including patients with chronic renal failure. We evaluated COVID-19 incidence among our hemodialysis patients and investigated the most probable immune mechanisms against COVID-19. Materials and Methods: Baskent University has 21 dialysis centers across Turkey, with 2420 patients on hemodialysis and 30 on peritoneal dialysis. Among these, we retrospectively evaluated 602 patients (257 female/345 male) with chronic renal failure receiving hemodialysis as renal replacement therapy; 7 patients (1.1%) were infected with SARS-CoV-2. We retrospectively collected patient demographic characteristics, clinical data, and immunological factors affecting the clinical course of the disease. We divided patients into groups and included 2 control groups ( individuals with normal renal functions): group I included COVID-19-positive patients with normal renal function, group II included COVID-19-positive hemodialysis patients, group III included COVID-19-negative hemodialysis patients, and group IV included COVID-19-negative patients with normal renal function. Lymphocyte subsets in peripheral blood and typing of human leukocyte antigens were analyzed in all groups, with killer cell immunoglobulin-like receptor genes analyzed only in COVID-19-positive patients and healthy controls. Results: No deaths occurred among the 7 COVID-19-positive hemodialysis patients. Group I patients were significantly older than patients in groups II and III ( P = .039, P = .030, respectively) but not significantly different from group IV (P = .060). Absolute counts of natural killer cells in healthy controls were higher than in other groups (but not significantly). Activated T cells were significantly increased in both COVID-19-positive groups versus COVID-19-negative groups. Groups showed significant differences in C and DQ loci with respect to distribution of alleles in both HLA classes. Conclusions: Although immunocompromised patients are at greater risk for COVID-19, we found lower COVID-19 incidence in our hemodialysis patients, which should be further investigated in in vitro and molecular studies.en_US
dc.language.isoengen_US
dc.relation.isversionof10.6002/ect.2020.0194en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic renal failureen_US
dc.subjectPandemicen_US
dc.subjectSARS-CoV-2en_US
dc.titleIncidence and Immunologic Analysis of Coronavirus Disease (COVID-19) in Hemodialysis Patients: A Single-Center Experienceen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL AND CLINICAL TRANSPLANTATIONen_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.startpage275en_US
dc.identifier.endpage283en_US
dc.identifier.wos000537447100003en_US
dc.contributor.pubmedID32519618en_US
dc.contributor.orcID0000-0001-8287-6572en_US
dc.contributor.orcID0000-0003-1511-7634en_US
dc.contributor.orcID0000-0002-5735-4315en_US
dc.contributor.orcID0000-0002-0993-9917en_US
dc.contributor.orcID0000-0002-8726-3369en_US
dc.contributor.orcID0000-0002-3171-8926en_US
dc.contributor.orcID0000-0002-8360-6459en_US
dc.contributor.orcID0000-0002-3462-7632en_US
dc.contributor.orcID0000-0002-8211-4065en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDJ-3707-2015en_US
dc.contributor.researcherIDAAU-1810-2020en_US
dc.contributor.researcherIDAAF-4610-2019en_US
dc.contributor.researcherIDAAC-5566-2019en_US
dc.contributor.researcherIDAAA-3068-2021en_US
dc.contributor.researcherIDAAK-4089-2021en_US
dc.contributor.researcherIDAAB-5175-2021en_US
dc.contributor.researcherIDAAJ-8097-2021en_US
dc.contributor.researcherIDR-9398-2019en_US


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