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dc.contributor.authorCelebi, Nevin
dc.date.accessioned2022-06-23T11:04:37Z
dc.date.available2022-06-23T11:04:37Z
dc.date.issued2021
dc.identifier.issn0265-2048en_US
dc.identifier.urihttp://hdl.handle.net/11727/7129
dc.description.abstractAim The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD). Methods Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheologic and mechanical properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw oedema and radiant heat tail-flick method, respectively. Results The ETD-NS with approximately 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm(2) for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD. Conclusions ETD-NS based gel formulation is promising for topical delivery of ETD.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/02652048.2021.1895344en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEtodolacen_US
dc.subjectnanosuspensionen_US
dc.subjectgel formulationen_US
dc.subjectdermal drug deliveryen_US
dc.subjectpermeationen_US
dc.titleEtodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluationen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF MICROENCAPSULATIONen_US
dc.identifier.volume38en_US
dc.identifier.issue4en_US
dc.identifier.startpage218en_US
dc.identifier.endpage232en_US
dc.identifier.wos000631943700001en_US
dc.identifier.scopus2-s2.0-85102919867en_US
dc.contributor.pubmedID33752553en_US
dc.contributor.orcID0000-0002-6402-5042en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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