dc.contributor.author | Celebi, Nevin | |
dc.date.accessioned | 2022-06-23T11:04:37Z | |
dc.date.available | 2022-06-23T11:04:37Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0265-2048 | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/7129 | |
dc.description.abstract | Aim
The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD).
Methods
Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheologic and mechanical properties were investigated. In vitro and ex vivo permeability studies were performed. Topical anti-inflammatory and analgesic activity were evaluated in regard to carrageenan-induced inflammatory paw oedema and radiant heat tail-flick method, respectively.
Results
The ETD-NS with approximately 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cm(2) for both gels. Dermal permeation of ETD from NS-HEC gel (7.18%) was found significantly higher than the NS-HPMC gel (4.56%). Enhanced anti-inflammatory and analgesic activity of NS-HEC gels were observed in comparison with micronised ETD.
Conclusions
ETD-NS based gel formulation is promising for topical delivery of ETD. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1080/02652048.2021.1895344 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Etodolac | en_US |
dc.subject | nanosuspension | en_US |
dc.subject | gel formulation | en_US |
dc.subject | dermal drug delivery | en_US |
dc.subject | permeation | en_US |
dc.title | Etodolac nanosuspension based gel for enhanced dermal delivery: in vitro and in vivo evaluation | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF MICROENCAPSULATION | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 218 | en_US |
dc.identifier.endpage | 232 | en_US |
dc.identifier.wos | 000631943700001 | en_US |
dc.identifier.scopus | 2-s2.0-85102919867 | en_US |
dc.contributor.pubmedID | 33752553 | en_US |
dc.contributor.orcID | 0000-0002-6402-5042 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |