Show simple item record

dc.contributor.authorAyhan, Ali
dc.contributor.authorCelik, Husnu
dc.contributor.authorTunc, Mehmet
dc.contributor.authorKuscu, Esra
dc.contributor.authorAkilli, Huseyin
dc.date.accessioned2022-06-24T07:28:43Z
dc.date.available2022-06-24T07:28:43Z
dc.date.issued2021
dc.identifier.issn0147-0272en_US
dc.identifier.uri
dc.identifier.urihttp://hdl.handle.net/11727/7142
dc.description.abstractTo assess the clinicopathological features, prognostic factors, and survival rates associated with uterine leiomyosarcoma (uLMS). Databases from 15 participating gynecological oncology centers in Turkey were searched retrospectively for women who had been treated for stage I-IV uLMS between 1996 and 2018. Of 302 consecutive women with uLMS, there were 234 patients with Federation of Gynecology and Obstetrics (FIGO) stage I disease and 68 with FIGO stage II-IV disease. All patients underwent total hysterectomy. Lymphadenectomy was performed in 161 (54.5%) cases. A total of 195 patients received adjuvant treatment. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 42% and 54%, respectively. Presence of lymphovascular space invasion (LVSI), higher degree of nuclear atypia, and absence of lymphadenectomy were negatively correlated with DFS, while LVSI, mitotic count, higher degree of nuclear atypia, FIGO stage II-IV disease, and suboptimal surgery significantly decreased OS. LVSI and higher degree of nuclear atypia appear to be prognostic indicators for uLMS. Lymphadenectomy seems to have a significant effect on DFS but not on OS. (c) 2021 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.currproblcancer.2021.100712en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUterine leiomyosarcomaen_US
dc.subjectLymphadenectomyen_US
dc.subjectLymphovascular space invasionen_US
dc.titlePrognostic factors and survival outcomes of women with uterine leiomyosarcoma: A Turkish Uterine Sarcoma Group Study-003en_US
dc.typearticleen_US
dc.relation.journalCURRENT PROBLEMS IN CANCERen_US
dc.contributor.departmentBaşkent Üniversitesien_US
dc.identifier.volume45en_US
dc.identifier.issue5en_US
dc.identifier.startpage1en_US
dc.identifier.endpage10en_US
dc.identifier.wos000727552100009en_US
dc.identifier.scopus2-s2.0-85102036836en_US
dc.contributor.pubmedID33685725en_US
dc.contributor.orcID0000-0002-5240-8441en_US
dc.contributor.orcID0000-0002-8646-0619en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAX-3230-2020en_US
dc.contributor.researcherIDAAA-6962-2022en_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record