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dc.contributor.authorErol, Cigdem
dc.contributor.authorAzap, Ozlem
dc.date.accessioned2022-06-24T07:36:24Z
dc.date.available2022-06-24T07:36:24Z
dc.date.issued2021
dc.identifier.issn1217-8950en_US
dc.identifier.urihttp://hdl.handle.net/11727/7143
dc.description.abstractThis study aimed to detect carbapenemase genes and to determine the in vitro susceptibility of Ceftazidime-Avibactam (CZA) in Enterobacterales isolates. Carbapenemase genes were detected by polymerase chain reaction. CZA sensitivity of isolates was evaluated with broth microdilution (BMD) and disk diffusion methods. A total of 318 carbapenem-resistant Enterobacterales isolates were included. Most of the isolates (n = 290, 91.2%) were identified as Klebsiella pneumoniae. The most common carbapenemase type was OXA-48 (n = 82, 27.6%). CZA susceptibility was evaluated in 84 isolates with OXA-48 and KPC carbapenemase activity. Both BMD and disk diffusion methods revealed that 95.2% of the isolates were sensitive to CZA; whereas, 4 (4.76%) isolates were resistant to CZA. Among colistin resistant isolates, 96.5% (n = 80) of them were susceptible to CZA. Our study demonstrated high in vitro efficacy of CZA in Enterobacterales isolates producing OXA-48 carbapenemase. High susceptibility rates against colistin resistant isolates which generally are also pan drug resistant, makes CZA a promising therapeutic choice for difficult-to-treat infections. Due to its high correlation with the BMD, disk diffusion method is a suitable and more practical method in detecting CZA in vitro activity.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1556/030.2021.01525en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarbapenemaseen_US
dc.subjectceftazidime-avibactamen_US
dc.subjectcolistinen_US
dc.subjectEnterobacteralesen_US
dc.titleCeftazidime - Avibactam susceptibility among carbapenem-resistant Enterobacterales in a pilot study in Turkeyen_US
dc.typearticleen_US
dc.relation.journalACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICAen_US
dc.contributor.departmentBaşkent Üniversitesien_US
dc.identifier.volume68en_US
dc.identifier.issue4en_US
dc.identifier.startpage256en_US
dc.identifier.endpage261en_US
dc.identifier.wos000727197500005en_US
dc.contributor.pubmedID34324428en_US
dc.contributor.orcID0000-0002-2535-2534en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAJ-1219-2021en_US


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