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dc.contributor.authorMansour, Hana A.
dc.contributor.authorOzdal, Pinar C.
dc.contributor.authorKadayifcilar, Sibel
dc.contributor.authorTugal-Tutkun, Ilknur
dc.contributor.authorEser-Ozturk, Hilal
dc.contributor.authorYalcindag, F. Nilufer
dc.contributor.authorPetrushkin, Harry
dc.contributor.authorChan, Errol W.
dc.contributor.authorBelfaiza, Soukaina
dc.contributor.authorKaradag, Remzi
dc.contributor.authorGungor, Sirel Gur
dc.contributor.authorParodi, Maurizio Battaglia
dc.contributor.authorMansour, Ahmad M.
dc.date.accessioned2022-08-03T11:57:01Z
dc.date.available2022-08-03T11:57:01Z
dc.date.issued2021
dc.identifier.issn0950-222Xen_US
dc.identifier.urihttp://hdl.handle.net/11727/7218
dc.description.abstractObjectives To analyse the entity of retinal vasculitis, including frosted branch angiitis (FBA), or retina vascular occlusion in patients with familial Mediterranean fever (FMF). Methods Retrospective collaborative case series using invitation by email to uveitis specialists around the Mediterranean basin. This series was combined with a literature review. Exclusion criteria included infectious diseases, Behcet's disease or other autoimmune diseases. Results A total of 16 patients (21 eyes) had FMF and retinal vasculitis (FBA 11 patients, mild retinal vasculitis 5 patients). The mean age at onset of vasculitis was 29.5 +/- 13.4 (range 9-62) with a female to male ratio of 9 to 7. In 19 eyes treated with various forms of corticosteroid and/or immunosuppression, the mean initial spectacle-corrected visual acuity improved from 6/194 to 6/10.5 at the last mean follow-up of 29.0 +/- 34.9 months (p < 0.001). The most common FEVR mutations were M680I and M694V. In addition, retinal vascular occlusions included one case of central retinal artery occlusion and one case of branch retinal artery occlusion. Conclusion FBA and milder forms of retinal vasculitis are associated with FMF. Therapy involves an increase in colchicine dosage in early cases, a long period of oral corticosteroid, intravitreal dexamethasone implant or periocular corticosteroid in select cases, and combination therapy with systemic immunosuppression in severe cases. FMF needs to be included in the differential diagnosis of retinal vasculitis.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1038/s41433-021-01822-5en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCHOROIDAL THICKNESSen_US
dc.subjectADULT PATIENTSen_US
dc.subjectANGIOGRAPHYen_US
dc.subjectCOLCHICINEen_US
dc.subjectSYMPTOMSen_US
dc.subjectCHILDRENen_US
dc.titleFamilial Mediterranean fever associated frosted branch angiitis, retinal vasculitis and vascular occlusionen_US
dc.typearticleen_US
dc.relation.journalEYEen_US
dc.identifier.wos000713538900002en_US
dc.identifier.scopus2-s2.0-85118371951en_US
dc.contributor.pubmedID34725467en_US
dc.contributor.orcID0000-0001-6178-8362en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAD-5967-2021en_US


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