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dc.contributor.authorSuslu, Incilay
dc.contributor.authorKablan, Sevilay Erdogan
dc.contributor.authorSafak, Cihat
dc.contributor.authorSimsek, Rahime
dc.date.accessioned2022-09-16T11:02:04Z
dc.date.available2022-09-16T11:02:04Z
dc.date.issued2021
dc.identifier.issn2630-6344en_US
dc.identifier.urihttps://jrespharm.com/uploads/pdf/pdf_MPJ_869.pdf
dc.identifier.urihttp://hdl.handle.net/11727/7801
dc.description.abstractAntioxidants used in different medical and industrial fields in order to prevent and delay oxidative stress. They play a crucial role in the protecting biological systems against many diseases. 1,4-dihydropyridines are known as calcium channel modulators. Electrochemical techniques are simple, cheap and fast detection techniques and require small amounts of sample, so they offer advantages over commonly used analytical methods. Voltammetric methods have been applied to investigated the antioxidant activity of compounds in different fields. The proposed work is aimed at examining the electrochemical behavior of the 1,4-dihydropyridines by differential pulse voltammetry and hence the assessment of its antioxidant activity from the cathodic reduction peak of oxygen values. The peak current due to oxygen reduction was found to be proportional to the 1,4-dihydropyridines concentration of 0.1 - 0.5 mg/mL. The coefficient of antioxidant activity of 1,4-dihydropyridine derivatives were calculated and compared each other. Nifedipine used as a reference drug that is known as the calcium channel modulator and it is used to compare the antioxidant activities of 1,4-dihydropyridine-derived compounds.en_US
dc.language.isoengen_US
dc.relation.isversionof10.35333/jrp.2021.288en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHexahydroquinoline derivativesen_US
dc.subjectnifedipineen_US
dc.subjectantioxidant activityen_US
dc.subjectdifferential pulse voltammetryen_US
dc.titleElectrochemical Detection of Antioxidant Activities of 4-Indolyl-5-Oxo-6,6 (Or 7,7)-Dimethyl-1,4,5,6,7,8-Hexahydroquinoline Derivativesen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF RESEARCH IN PHARMACYen_US
dc.identifier.volume25en_US
dc.identifier.issue1en_US
dc.identifier.startpage52en_US
dc.identifier.endpage62en_US
dc.identifier.wos000610833200006en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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