OPEC Study: An International Multicenter Study Of Ovarian Preservation In Endometrial Cancers

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Date
2022
Author
Akgor, Utku
Ayhan, Ali
Shushkevich, Alexander
Ozdal, Bulent
Angelou, Kyveli
Akbayir, Ozgur
Kaidarova, Dilyara
Ulrikh, Elena
Stepanyan, Artem
Ortac, Firat
Aliyev, Shamistan
Ozgul, Nejat
Taranenka, Siarhei
Haberal, Ali
Salman, Coskun
Seyhan, Alper
Selcuk, Ilker
Haidopoulos, Dimitrios
Akilli, Huseyin
Bolatbekova, Raikhan
Alaverdyan, Areg
Taskin, Salih
Murshudova, Sabina
Batur, Meltem
Berlev, Igor
Gultekin, Murat
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Abstract
Objective To evaluate the feasibility and oncological safety of ovarian preservation in early stage endometrial adenocarcinoma (EC) patients aged 40 and below. Methods A total of 11 institutions from eight countries participated in the study. 169 of 5898 patients aged <= 40 years were eligible for the study. Patients with EC treated between March 2007 and January 2019 were retrospectively assessed. Results The median duration of follow-up after EC diagnosis was 59 months (4-187). Among 169 participants, ovarian preservation surgery (OPS) was performed in 54 (31.9%), and BSO was performed in 115 (68.1%) patients. Although patients younger than 30 years of age were more likely to have OPS than patients aged 30 to 40 years (20.4% vs. 9.6%, P = 0.021), there was no significant difference by the mean age. There were no other relevant baseline differences between OPS and BSO groups. The Kaplan-Meier analysis revealed no difference in either the overall survival (P = 0.955) or recurrence-free survival (P = 0.068) among patients who underwent OPS, and BSO. Conclusion OPS appears to be safe without having any adverse impact on survival in women aged <= 40 years with FIGO Stage I EC.
URI
http://hdl.handle.net/11727/8194
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